Personalised Early Risk Prediction, Prevention and Intervention based on AI and Big Data Technologies
The ageing of the population together with the rising burden of chronic conditions (incl. mental diseases) and multi-morbidity bring an ever increasing demand to strengthen disease prevention and integrate service delivery around people's needs for health and social care.
It is widely recognised that health systems must put more emphasis on prevention and adopt a person-centred rather than a disease-centred approach. The goal must be to overcome service fragmentation and to move towards integration and coordination of interventions along the continuum of care.
Personalised early risk prediction models, estimating the probability that a specific event occurs in a given individual over a predefined time, can enable earlier and better intervention, prevent negative consequences on a person’s quality of life and thus result in improved individual health outcomes.
The challenge is to develop and validate these comprehensive models based on AI or other state of the art technologies for prediction, prevention and intervention using multiple available data resources and to integrate them in personalised health and care pathways that empower individuals to actively contribute to risk mitigation, prevention and targeted intervention.
Proposals should build on results of projects  and the state of the art in ICT for early risk prediction and introduce innovative ICT solutions through data, data analytics, advanced or novel digital technologies, services, products, organisational changes, and citizens data ownership, that lead to more effective health and care systems. These innovative ICT based solutions may address one or multiple conditions and explore ways of inducing adequate personalised preventive measures (e.g. behavioural change, diet, interventions, medication, primary prevention) from advanced predictive models. Sustainable behaviour change refers to efforts to change people's personal habits to prevent disease, stimulate healthy people to monitor their health parameters and thus lowering the risk of developing (chronic) conditions.
Proposals should build on the use of already existing and/or new data generated by individuals, health professionals and other service providers (including but not limited to data collected through IoT enabled devices, wearables, mobile devices, data source networks or data lakes etc. collected outside the controlled environment of clinical trials) by citizens, healthcare professionals, public authorities and industry, with a view to developing personalised early risk prediction, prevention and intervention approaches that meet the needs of individuals while providing them with adequate information to support informed decision making, improve the uptake of preventive approaches and lead to better health outcomes.
Proposals should also include actions aimed at increasing health literacy, including the role of the citizen as owner of his or her own personal data, as well as advancing health and care professionals' proficiency in novel, data-oriented health services through the use of digital solutions to increase knowledge about diseases and help them in the interpretation of symptoms and effects (e.g. with visualisations like dashboards, etc.), notably of early warning signs and medical information. Early warning signs relay to either healthy people monitoring several body parameters e.g. to conduct healthy life styles and increase physical activity levels or to the detection of the deterioration of the condition of already diseased patients. The latter could include advanced prediction models from aggregated patient data of certain health events/complications.
Proposals are expected to be built on realistic scenarios for new health and care pathways, and should integrate multi-disciplinary research involving behavioural, sociological, medical and other relevant disciplines. Stakeholder engagement (esp. considering vulnerable user groups, i.e. persons belonging, or perceived to belong, to groups that are in a disadvantaged position or marginalised, for example, elderly people, persons with special needs or chronic diseases) should be part of the research design for an agile approach to ensuring that relevant user needs (including social, age and gender aspects) are met and solutions find acceptance by users. Full account should be taken of ethical and legal aspects e.g. data protection, privacy and data security. This action should create a clear and coherent set of recommendations or guidelines for public health authorities in Europe together with a strategy to support their implementation.
No large-scale piloting or clinical trials are expected in this Research and Innovation Action. However, proposals should include validation (testing on a prototype and/or proof of concept) and demonstration of feasibility of their respective models, technologies and scenarios.
The Commission considers that proposals requesting a contribution from the EU of between EUR 4 and 6 million would allow this specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts. Participation of SMEs is encouraged.
The proposal should provide appropriate indicators to measure its progress and specific impact in the following areas:
- Evidence of the benefits of delivering adequate information regarding personalised risk prediction, prevention and intervention, based on proof of concept and involvement and specified roles of relevant stakeholders.
- Clear improvements of outcomes for individuals, care systems and wider society from prevention measures and interventions based on personalised early risk prediction in comparison with current practices.
- Usefulness and effectiveness of integration and coordination of interventions in new health and care pathways based on person-centred early risk prediction, prevention and intervention models.
- Realise large-scale collection of user-generated data in compliance with data protection, privacy and security rules and principles.
- Support integration with tools and services under the European Open Science Cloud.
 For example project outcomes from the H2020 topic PHC-21-2015
Illustration Photo: Personalized healthcare app (credits: Juhan Sonin / Flickr Creative Commons Attribution 2.0 Generic (CC BY 2.0))